This gene encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rat, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. In rat, the C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RCBTB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RCBTB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RCBTB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:49,443,422–49,445,325 | 141.4 kb | Distal (>10kb) Multiome | 929 | |
| chr13:49,495,326–49,496,757 | 89.4 kb | Distal (>10kb) Multiome | 729 | |
| chr13:49,559,958–49,561,357 | 24.7 kb | Distal (>10kb) Multiome | 297 | |
| chr13:49,584,820–49,586,364 | 124 bp | At TSS Multiome | 809 | |
| chr13:49,628,213–49,628,711 | 42.9 kb | Distal (>10kb) Multiome | 271 | |
| chr13:49,635,533–49,636,248 | 50.2 kb | Distal (>10kb) Multiome | 74 | |
| chr13:49,664,328–49,664,981 | 79.2 kb | Distal (>10kb) Multiome | 75 | |
| chr13:49,690,816–49,691,882 | 105.9 kb | Distal (>10kb) Multiome | 847 | |
| chr13:49,791,339–49,793,749 | 207.3 kb | Distal (>10kb) Multiome | 930 | |
| chr13:49,847,783–49,848,275 | 262.6 kb | Distal (>10kb) Multiome | 505 |
Genomic view of the RCBTB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.