Enables DNA binding activity; RNA binding activity; and ubiquitin protein ligase activity. Involved in protein polyubiquitination. Located in cell surface; intracellular membrane-bounded organelle; and membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for RC3H2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RC3H2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RC3H2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:122,827,785–122,828,901 | 76.8 kb | Distal (>10kb) Multiome | 765 | |
| chr9:122,904,531–122,905,694 | 77 bp | At TSS Multiome | 890 | |
| chr9:122,912,955–122,913,476 | 8.0 kb | Proximal (<10kb) Multiome | 779 | |
| chr9:122,930,976–122,932,127 | 26.3 kb | Distal (>10kb) Multiome | 857 | |
| chr9:122,940,508–122,941,931 | 35.7 kb | Distal (>10kb) Multiome | 767 | |
| chr9:123,353,960–123,354,559 | 448.9 kb | Distal (>10kb) Multiome HiCAR | 362 | |
| chr9:123,359,538–123,361,097 | 455.1 kb | Distal (>10kb) Multiome HiCAR | 570 |
Genomic view of the RC3H2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.