Predicted to enable U12 snRNA binding activity and pre-mRNA intronic binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U12-type spliceosomal complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RBM41. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM41 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM41, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:106,932,851–106,934,117 | 185.1 kb | Distal (>10kb) Multiome | 315 | |
| chrX:106,999,512–107,000,567 | 118.6 kb | Distal (>10kb) Multiome | 501 | |
| chrX:107,118,344–107,118,954 | at TSS | At TSS | 443 | |
| chrX:107,205,778–107,206,873 | 87.6 kb | Distal (>10kb) Multiome | 440 | |
| chrX:107,324,517–107,325,343 | 206.1 kb | Distal (>10kb) Multiome | 215 | |
| chrX:107,355,186–107,356,118 | 236.8 kb | Distal (>10kb) Multiome | 63 |
Genomic view of the RBM41 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.