Enables RNA binding activity. Predicted to be located in cytoplasm and nuclear speck. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RBM27. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM27 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM27, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:145,936,249–145,937,190 | 267.0 kb | Distal (>10kb) Multiome | 653 | |
| chr5:146,026,278–146,026,799 | 177.1 kb | Distal (>10kb) Multiome | 138 | |
| chr5:146,073,032–146,074,223 | 130.0 kb | Distal (>10kb) Multiome | 179 | |
| chr5:146,182,165–146,183,510 | 20.8 kb | Distal (>10kb) Multiome | 994 | |
| chr5:146,202,953–146,204,079 | 79 bp | At TSS Multiome | 825 | |
| chr5:146,338,076–146,339,360 | 135.2 kb | Distal (>10kb) Multiome | 195 | |
| chr5:146,344,641–146,346,403 | 141.3 kb | Distal (>10kb) Multiome | 236 | |
| chr5:146,446,778–146,447,873 | 243.6 kb | Distal (>10kb) Multiome | 960 |
Genomic view of the RBM27 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.