Enables RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RBM12B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM12B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM12B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:92,094,433–92,096,717 | 1645.6 kb | Distal (>10kb) Multiome HiCAR | 551 | |
| chr8:93,582,408–93,584,018 | 157.3 kb | Distal (>10kb) Multiome | 191 | |
| chr8:93,699,869–93,701,509 | 40.5 kb | Distal (>10kb) Multiome | 609 | |
| chr8:93,731,017–93,731,276 | 9.7 kb | Proximal (<10kb) | 128 | |
| chr8:93,740,245–93,741,472 | 25 bp | At TSS Multiome | 876 | |
| chr8:93,746,443–93,746,614 | 5.4 kb | Proximal (<10kb) | 31 | |
| chr8:93,748,775–93,749,056 | 7.8 kb | Proximal (<10kb) | 127 | |
| chr8:93,750,573–93,751,014 | 9.6 kb | Proximal (<10kb) | 27 | |
| chr8:93,754,676–93,755,350 | 13.9 kb | Distal (>10kb) Multiome | 573 | |
| chr8:93,915,949–93,918,134 | 175.7 kb | Distal (>10kb) Multiome | 821 | |
| chr8:93,943,280–93,944,641 | 203.1 kb | Distal (>10kb) Multiome | 354 | |
| chr8:93,952,630–93,953,256 | 212.0 kb | Distal (>10kb) Multiome HiCAR | 63 | |
| chr8:93,991,163–93,992,088 | 250.6 kb | Distal (>10kb) Multiome | 561 |
Genomic view of the RBM12B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.