Transcription factors with Perturb-seq knockdown data for RBFADN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBFADN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBFADN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:79,797,637–79,799,132 | 248.9 kb | Distal (>10kb) Multiome | 246 | |
| chr18:79,950,747–79,952,381 | 95.2 kb | Distal (>10kb) Multiome | 606 | |
| chr18:79,960,055–79,960,750 | 86.4 kb | Distal (>10kb) Multiome | 94 | |
| chr18:79,964,253–79,964,855 | 82.3 kb | Distal (>10kb) Multiome | 536 | |
| chr18:79,988,046–79,989,235 | 58.4 kb | Distal (>10kb) Multiome | 832 | |
| chr18:80,033,036–80,034,844 | 12.7 kb | Distal (>10kb) Multiome | 863 | |
| chr18:80,108,658–80,110,068 | 62.2 kb | Distal (>10kb) Multiome | 673 | |
| chr18:80,119,162–80,119,666 | 72.5 kb | Distal (>10kb) Multiome | 42 | |
| chr18:80,147,532–80,148,374 | 100.9 kb | Distal (>10kb) Multiome | 357 | |
| chr18:80,245,958–80,247,961 | 199.6 kb | Distal (>10kb) Multiome | 405 |
Genomic view of the RBFADN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.