This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for RBBP7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBBP7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBBP7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:16,719,154–16,719,979 | 150.8 kb | Distal (>10kb) Multiome | 716 | |
| chrX:16,771,090–16,772,164 | 98.7 kb | Distal (>10kb) Multiome | 626 | |
| chrX:16,786,080–16,787,269 | 84.0 kb | Distal (>10kb) Multiome | 646 | |
| chrX:16,869,468–16,871,503 | 115 bp | At TSS Multiome | 687 | |
| chrX:16,946,195–16,947,346 | 76.3 kb | Distal (>10kb) Multiome | 329 | |
| chrX:17,007,183–17,007,806 | 137.1 kb | Distal (>10kb) Multiome | 134 |
Genomic view of the RBBP7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.