Predicted to enable G protein activity; GTP binding activity; and transforming growth factor beta receptor binding activity. Predicted to act upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RASL11B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RASL11B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RASL11B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:52,657,281–52,658,511 | 204.4 kb | Distal (>10kb) Multiome | 230 | |
| chr4:52,658,663–52,660,293 | 202.9 kb | Distal (>10kb) Multiome | 590 | |
| chr4:52,711,775–52,713,336 | 150.0 kb | Distal (>10kb) Multiome HiCAR | 936 | |
| chr4:52,721,591–52,722,821 | 139.9 kb | Distal (>10kb) Multiome HiCAR | 629 | |
| chr4:52,750,745–52,752,040 | 110.7 kb | Distal (>10kb) Multiome HiCAR | 368 | |
| chr4:52,834,642–52,835,399 | 27.3 kb | Distal (>10kb) Multiome | 83 | |
| chr4:52,861,376–52,863,512 | 95 bp | At TSS Multiome | 543 | |
| chr4:52,868,095–52,868,485 | 5.8 kb | Proximal (<10kb) | 70 | |
| chr4:52,873,892–52,874,335 | 11.8 kb | Distal (>10kb) Multiome | 112 |
Genomic view of the RASL11B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.