Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in early endosome; late endosome; and midbody. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RASGEF1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RASGEF1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RASGEF1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:81,214,271–81,215,901 | 829.3 kb | Distal (>10kb) Multiome | 315 | |
| chr4:81,365,957–81,366,689 | 678.0 kb | Distal (>10kb) Multiome | 115 | |
| chr4:81,421,371–81,422,293 | 622.3 kb | Distal (>10kb) Multiome HiCAR | 410 | |
| chr4:81,467,476–81,467,676 | 4.3 kb | Proximal (<10kb) | 98 | |
| chr4:81,470,519–81,472,674 | 572.3 kb | Distal (>10kb) Multiome | 675 | |
| chr4:81,473,789–81,474,437 | 1.9 kb | Proximal (<10kb) | 67 | |
| chr4:81,486,328–81,487,160 | 557.5 kb | Distal (>10kb) Multiome | 174 | |
| chr4:81,650,608–81,651,709 | 393.2 kb | Distal (>10kb) Multiome | 243 | |
| chr4:81,844,544–81,846,038 | 198.8 kb | Distal (>10kb) Multiome HiCAR | 320 | |
| chr4:82,042,782–82,045,151 | 245 bp | At TSS Multiome | 535 | |
| chr4:82,284,318–82,285,814 | 240.9 kb | Distal (>10kb) Multiome | 566 |
Genomic view of the RASGEF1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.