This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for RASA3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RASA3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RASA3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:113,860,084–113,861,280 | 271.9 kb | Distal (>10kb) Multiome | 327 | |
| chr13:114,131,895–114,133,058 | 21 bp | At TSS Multiome | 456 | |
| chr13:114,226,784–114,227,286 | 94.4 kb | Distal (>10kb) Multiome HiCAR | 409 | |
| chr13:114,234,692–114,235,425 | 102.3 kb | Distal (>10kb) Multiome | 952 | |
| chr13:114,261,338–114,261,888 | 129.0 kb | Distal (>10kb) Multiome | 51 | |
| chr13:114,280,965–114,282,252 | 149.1 kb | Distal (>10kb) Multiome | 896 | |
| chr13:114,314,168–114,314,907 | 181.8 kb | Distal (>10kb) Multiome | 884 |
Genomic view of the RASA3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.