Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RARS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RARS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RARS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:168,268,702–168,269,867 | 216.9 kb | Distal (>10kb) Multiome HiCAR | 609 | |
| chr5:168,291,138–168,293,102 | 194.8 kb | Distal (>10kb) Multiome | 633 | |
| chr5:168,295,589–168,296,149 | 190.7 kb | Distal (>10kb) Multiome | 209 | |
| chr5:168,328,780–168,329,633 | 157.3 kb | Distal (>10kb) Multiome | 243 | |
| chr5:168,334,311–168,335,028 | 151.7 kb | Distal (>10kb) Multiome | 189 | |
| chr5:168,486,057–168,486,891 | 45 bp | At TSS Multiome | 846 | |
| chr5:168,528,975–168,529,622 | 42.8 kb | Distal (>10kb) Multiome | 229 | |
| chr5:168,578,780–168,580,390 | 93.2 kb | Distal (>10kb) Multiome | 938 | |
| chr5:168,580,861–168,581,396 | 94.7 kb | Distal (>10kb) Multiome | 158 |
Genomic view of the RARS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.