This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014]
Transcription factors with Perturb-seq knockdown data for RARRES2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RARRES2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RARRES2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:149,870,542–149,871,523 | 470.8 kb | Distal (>10kb) Multiome HiCAR | 81 | |
| chr7:149,872,817–149,874,446 | 467.8 kb | Distal (>10kb) Multiome HiCAR | 826 | |
| chr7:150,335,108–150,335,331 | 6.3 kb | Proximal (<10kb) | 98 | |
| chr7:150,335,460–150,335,682 | 6.0 kb | Proximal (<10kb) | 63 | |
| chr7:150,340,210–150,341,978 | 104 bp | At TSS Multiome | 416 | |
| chr7:150,368,010–150,369,898 | 27.0 kb | Distal (>10kb) Multiome | 1082 | |
| chr7:150,378,105–150,380,206 | 36.6 kb | Distal (>10kb) Multiome | 966 | |
| chr7:150,383,391–150,384,626 | 42.3 kb | Distal (>10kb) Multiome | 537 | |
| chr7:150,401,607–150,402,937 | 60.5 kb | Distal (>10kb) Multiome HiCAR | 307 | |
| chr7:150,404,616–150,406,417 | 63.8 kb | Distal (>10kb) Multiome HiCAR | 952 | |
| chr7:151,012,895–151,014,461 | 672.2 kb | Distal (>10kb) Multiome HiCAR | 414 | |
| chr7:151,017,863–151,019,302 | 676.8 kb | Distal (>10kb) Multiome HiCAR | 677 |
Genomic view of the RARRES2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.