RANGRF
RAN guanine nucleotide release factor | HSPC165, HSPC236, MOG1, RANGNRF

This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Member of: DE-1
Biological processes 51 terms
caveola (GO:0005901)channel activator activity (GO:0099103)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888)guanyl-nucleotide exchange factor activity (GO:0005085)guanyl-nucleotide exchange factor activity (GO:0005085)guanyl-nucleotide exchange factor activity (GO:0005085)heart contraction (GO:0060047)intercalated disc (GO:0014704)intercalated disc (GO:0014704)mitotic spindle assembly (GO:0090307)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)perinuclear region of cytoplasm (GO:0048471)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of membrane depolarization during cardiac muscle cell action potential (GO:1900827)positive regulation of protein localization to cell surface (GO:2000010)positive regulation of protein localization to cell surface (GO:2000010)positive regulation of protein localization to plasma membrane (GO:1903078)protein binding (GO:0005515)regulation of bundle of His cell action potential (GO:0098905)regulation of cardiac muscle cell action potential involved in regulation of contraction (GO:0098909)regulation of heart rate (GO:0002027)regulation of membrane depolarization (GO:0003254)regulation of membrane depolarization (GO:0003254)regulation of membrane depolarization during cardiac muscle cell action potential (GO:1900825)regulation of membrane depolarization during cardiac muscle cell action potential (GO:1900825)regulation of membrane depolarization during cardiac muscle cell action potential (GO:1900825)regulation of sodium ion transmembrane transport (GO:1902305)regulation of sodium ion transmembrane transport (GO:1902305)regulation of sodium ion transmembrane transport (GO:1902305)rough endoplasmic reticulum (GO:0005791)small GTPase binding (GO:0031267)small GTPase binding (GO:0031267)small GTPase binding (GO:0031267)small GTPase binding (GO:0031267)sodium channel regulator activity (GO:0017080)sodium channel regulator activity (GO:0017080)sodium channel regulator activity (GO:0017080)sodium channel regulator activity (GO:0017080)transmembrane transporter binding (GO:0044325)transmembrane transporter binding (GO:0044325)transmembrane transporter binding (GO:0044325)
Expression (TPM)
RANGRF — as a Regulated Gene

TFs regulating RANGRF 0 TFs

Transcription factors with Perturb-seq knockdown data for RANGRF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RANGRF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RANGRF

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RANGRF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:7,989,908–7,990,676 298.3 kb Distal (>10kb) Multiome 652
chr17:8,015,966–8,016,968 272.6 kb Distal (>10kb) Multiome 339
chr17:8,068,609–8,069,844 219.8 kb Distal (>10kb) Multiome 100
chr17:8,079,261–8,080,640 209.2 kb Distal (>10kb) Multiome 613
chr17:8,109,567–8,110,530 178.4 kb Distal (>10kb) Multiome 360
chr17:8,117,780–8,119,396 169.7 kb Distal (>10kb) Multiome 684
chr17:8,119,590–8,122,560 168.0 kb Distal (>10kb) Multiome 968
chr17:8,123,407–8,124,386 164.5 kb Distal (>10kb) Multiome 296
chr17:8,125,308–8,126,995 162.9 kb Distal (>10kb) Multiome 724
chr17:8,138,425–8,139,804 149.7 kb Distal (>10kb) Multiome 981
chr17:8,151,026–8,151,640 137.4 kb Distal (>10kb) Multiome 435
chr17:8,151,914–8,152,786 136.2 kb Distal (>10kb) Multiome 633
chr17:8,153,878–8,154,864 134.3 kb Distal (>10kb) Multiome 644
chr17:8,155,928–8,157,418 132.0 kb Distal (>10kb) Multiome 789
chr17:8,162,377–8,163,907 125.6 kb Distal (>10kb) Multiome 637
chr17:8,172,460–8,174,346 115.1 kb Distal (>10kb) Multiome 1196
chr17:8,175,900–8,176,943 112.2 kb Distal (>10kb) Multiome 601
chr17:8,185,937–8,188,084 100.9 kb Distal (>10kb) Multiome 1065
chr17:8,189,376–8,190,688 98.4 kb Distal (>10kb) Multiome 748
chr17:8,192,025–8,192,719 96.3 kb Distal (>10kb) Multiome 452
chr17:8,210,139–8,210,786 78.0 kb Distal (>10kb) Multiome 778
chr17:8,220,662–8,224,088 65.7 kb Distal (>10kb) Multiome 1171
chr17:8,226,529–8,227,280 61.9 kb Distal (>10kb) Multiome 565
chr17:8,247,519–8,249,589 39.3 kb Distal (>10kb) Multiome 914
chr17:8,283,414–8,283,637 5.0 kb Proximal (<10kb) 24
chr17:8,288,100–8,289,230 167 bp At TSS Multiome 751
chr17:8,295,073–8,296,021 6.9 kb Proximal (<10kb) Multiome 739
chr17:8,310,033–8,310,555 21.6 kb Distal (>10kb) Multiome 98
chr17:8,313,329–8,313,824 24.9 kb Distal (>10kb) Multiome 30
chr17:8,376,215–8,376,918 88.0 kb Distal (>10kb) Multiome 888
chr17:8,382,925–8,384,028 94.8 kb Distal (>10kb) Multiome 981
chr17:8,435,307–8,436,885 147.2 kb Distal (>10kb) Multiome 847
chr17:8,584,054–8,584,700 295.8 kb Distal (>10kb) Multiome 18

Genome Browser

Genomic view of the RANGRF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:7,979,908 – 8,594,700
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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