The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
Transcription factors with Perturb-seq knockdown data for RANBP17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RANBP17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RANBP17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:170,612,198–170,612,860 | 249.6 kb | Distal (>10kb) Multiome | 170 | |
| chr5:170,632,274–170,634,362 | 228.5 kb | Distal (>10kb) Multiome | 488 | |
| chr5:170,638,602–170,639,079 | 223.1 kb | Distal (>10kb) Multiome | 184 | |
| chr5:170,681,011–170,681,468 | 180.7 kb | Distal (>10kb) Multiome | 250 | |
| chr5:170,743,933–170,745,032 | 117.4 kb | Distal (>10kb) Multiome | 466 | |
| chr5:170,745,533–170,746,161 | 116.0 kb | Distal (>10kb) Multiome | 183 | |
| chr5:170,761,207–170,762,213 | 100.4 kb | Distal (>10kb) Multiome | 72 | |
| chr5:170,773,307–170,773,798 | 88.5 kb | Distal (>10kb) Multiome | 138 | |
| chr5:170,781,557–170,782,367 | 80.0 kb | Distal (>10kb) Multiome | 24 | |
| chr5:170,861,497–170,862,965 | 49 bp | At TSS Multiome | 508 | |
| chr5:170,947,264–170,947,948 | 85.6 kb | Distal (>10kb) Multiome | 70 |
Genomic view of the RANBP17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.