This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for RANBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RANBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RANBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:19,854,381–19,855,705 | 262.6 kb | Distal (>10kb) Multiome | 1014 | |
| chr22:19,891,576–19,892,031 | 225.8 kb | Distal (>10kb) Multiome | 631 | |
| chr22:19,959,058–19,959,828 | 158.0 kb | Distal (>10kb) Multiome | 576 | |
| chr22:19,962,339–19,962,798 | 155.0 kb | Distal (>10kb) Multiome | 442 | |
| chr22:19,986,350–19,987,426 | 130.3 kb | Distal (>10kb) Multiome | 539 | |
| chr22:20,016,068–20,017,437 | 100.7 kb | Distal (>10kb) Multiome | 640 | |
| chr22:20,020,662–20,021,745 | 96.5 kb | Distal (>10kb) Multiome | 718 | |
| chr22:20,079,663–20,080,743 | 37.4 kb | Distal (>10kb) Multiome | 994 | |
| chr22:20,116,628–20,118,048 | 168 bp | At TSS Multiome | 999 | |
| chr22:20,130,806–20,131,896 | 13.7 kb | Distal (>10kb) Multiome | 525 | |
| chr22:20,203,393–20,204,086 | 86.3 kb | Distal (>10kb) Multiome | 292 | |
| chr22:20,243,636–20,244,300 | 126.5 kb | Distal (>10kb) Multiome | 251 | |
| chr22:20,267,373–20,268,700 | 150.9 kb | Distal (>10kb) Multiome | 449 | |
| chr22:20,298,366–20,300,076 | 181.7 kb | Distal (>10kb) Multiome | 538 | |
| chr22:20,319,527–20,320,815 | 202.6 kb | Distal (>10kb) Multiome | 805 | |
| chr22:20,393,744–20,394,682 | 276.6 kb | Distal (>10kb) Multiome | 854 |
Genomic view of the RANBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.