Enables identical protein binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RALYL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RALYL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RALYL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:84,174,493–84,174,991 | 7.8 kb | Proximal (<10kb) | 9 | |
| chr8:84,175,988–84,176,169 | 6.6 kb | Proximal (<10kb) | 29 | |
| chr8:84,182,008–84,184,067 | 369 bp | At TSS Multiome | 417 | |
| chr8:84,184,356–84,185,395 | 2.0 kb | Proximal (<10kb) Multiome | 225 |
Genomic view of the RALYL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.