This gene encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) gene family. This protein may play a role in pre-mRNA splicing and in embryonic development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for RALY. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RALY upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RALY, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:33,720,042–33,720,684 | 273.4 kb | Distal (>10kb) Multiome | 584 | |
| chr20:33,731,496–33,732,906 | 261.5 kb | Distal (>10kb) Multiome | 1049 | |
| chr20:33,811,016–33,811,951 | 182.4 kb | Distal (>10kb) Multiome | 921 | |
| chr20:33,992,591–33,994,776 | 274 bp | At TSS Multiome | 1067 | |
| chr20:34,111,659–34,113,028 | 118.6 kb | Distal (>10kb) Multiome | 1069 |
Genomic view of the RALY locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.