Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]
Transcription factors with Perturb-seq knockdown data for RALGDS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RALGDS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RALGDS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:132,877,859–132,878,978 | 270.9 kb | Distal (>10kb) Multiome | 676 | |
| chr9:132,944,084–132,945,377 | 204.5 kb | Distal (>10kb) Multiome | 983 | |
| chr9:133,030,039–133,031,100 | 118.7 kb | Distal (>10kb) Multiome HiCAR | 998 | |
| chr9:133,059,688–133,060,833 | 88.8 kb | Distal (>10kb) Multiome HiCAR | 222 | |
| chr9:133,120,589–133,121,652 | 28.0 kb | Distal (>10kb) Multiome | 599 | |
| chr9:133,144,161–133,144,920 | 4.8 kb | Proximal (<10kb) Multiome | 776 | |
| chr9:133,147,412–133,149,938 | 44 bp | At TSS Multiome | 979 | |
| chr9:133,163,575–133,164,128 | 14.5 kb | Distal (>10kb) Multiome | 308 | |
| chr9:133,238,117–133,239,420 | 89.3 kb | Distal (>10kb) Multiome | 620 | |
| chr9:133,335,737–133,336,702 | 186.9 kb | Distal (>10kb) Multiome | 1038 | |
| chr9:133,347,434–133,348,830 | 198.8 kb | Distal (>10kb) Multiome | 893 | |
| chr9:133,356,029–133,357,223 | 207.2 kb | Distal (>10kb) Multiome | 648 | |
| chr9:133,375,394–133,376,740 | 226.9 kb | Distal (>10kb) Multiome | 834 | |
| chr9:133,417,747–133,418,516 | 268.8 kb | Distal (>10kb) Multiome | 1015 | |
| chr9:133,428,444–133,429,113 | 279.4 kb | Distal (>10kb) Multiome | 255 | |
| chr9:133,429,621–133,430,196 | 280.6 kb | Distal (>10kb) Multiome | 197 |
Genomic view of the RALGDS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.