The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for RAD23B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAD23B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAD23B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:107,028,710–107,029,579 | 254.1 kb | Distal (>10kb) Multiome | 180 | |
| chr9:107,130,867–107,131,827 | 152.0 kb | Distal (>10kb) Multiome | 242 | |
| chr9:107,190,398–107,191,484 | 92.5 kb | Distal (>10kb) Multiome | 207 | |
| chr9:107,194,086–107,194,633 | 88.9 kb | Distal (>10kb) Multiome | 154 | |
| chr9:107,282,454–107,284,453 | 946 bp | At TSS Multiome | 1069 | |
| chr9:107,288,753–107,288,982 | 5.5 kb | Proximal (<10kb) | 57 | |
| chr9:107,368,104–107,369,099 | 85.4 kb | Distal (>10kb) Multiome | 265 | |
| chr9:107,424,908–107,425,761 | 142.1 kb | Distal (>10kb) Multiome | 384 | |
| chr9:107,438,182–107,438,869 | 155.2 kb | Distal (>10kb) Multiome | 254 | |
| chr9:107,459,805–107,460,688 | 177.0 kb | Distal (>10kb) Multiome | 143 | |
| chr9:107,465,452–107,466,627 | 182.6 kb | Distal (>10kb) Multiome | 320 | |
| chr9:107,486,856–107,489,265 | 204.4 kb | Distal (>10kb) Multiome | 516 | |
| chr9:107,489,361–107,490,842 | 206.7 kb | Distal (>10kb) Multiome | 644 |
Genomic view of the RAD23B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.