RAD23A

RAD23 nucleotide excision repair protein A | HHR23A, MGC111083

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]

Member of: DE-11 Developmental clusters: GC2

Biological processes 33 terms

chromatin remodeling (GO:0006338)cytoplasm (GO:0005737)cytosol (GO:0005829)damaged DNA binding (GO:0003684)histone H4K20 demethylase activity (GO:0035575)histone H4K20 demethylase activity (GO:0035575)kinase binding (GO:0019900)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleotide-excision repair (GO:0006289)nucleotide-excision repair (GO:0006289)nucleotide-excision repair (GO:0006289)nucleus (GO:0005634)nucleus (GO:0005634)polyubiquitin modification-dependent protein binding (GO:0031593)polyubiquitin modification-dependent protein binding (GO:0031593)polyubiquitin modification-dependent protein binding (GO:0031593)positive regulation of cell cycle (GO:0045787)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)positive regulation of viral genome replication (GO:0045070)proteasome binding (GO:0070628)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein destabilization (GO:0031648)protein-containing complex (GO:0032991)regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434)regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434)single-stranded DNA binding (GO:0003697)single-stranded DNA binding (GO:0003697)ubiquitin binding (GO:0043130)ubiquitin-specific protease binding (GO:1990381)

Expression (TPM)

TFs regulating RAD23A 0 TFs

Transcription factors with Perturb-seq knockdown data for RAD23A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAD23A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RAD23A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAD23A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:12,647,538–12,648,022	298.1 kb	Distal (>10kb) Multiome	126
chr19:12,656,871–12,657,566	288.7 kb	Distal (>10kb) Multiome	254
chr19:12,666,317–12,667,225	279.1 kb	Distal (>10kb) Multiome	495
chr19:12,669,351–12,669,939	276.3 kb	Distal (>10kb) Multiome	777
chr19:12,681,003–12,682,117	264.4 kb	Distal (>10kb) Multiome	994
chr19:12,696,035–12,696,970	249.2 kb	Distal (>10kb) Multiome	806
chr19:12,702,968–12,703,602	242.6 kb	Distal (>10kb) Multiome	121
chr19:12,721,692–12,723,084	223.4 kb	Distal (>10kb) Multiome	807
chr19:12,723,726–12,724,142	221.8 kb	Distal (>10kb) Multiome	539
chr19:12,734,221–12,735,284	211.1 kb	Distal (>10kb) Multiome	882
chr19:12,736,470–12,737,780	208.7 kb	Distal (>10kb) Multiome	742
chr19:12,757,454–12,758,297	188.1 kb	Distal (>10kb) Multiome	588
chr19:12,765,876–12,766,545	179.6 kb	Distal (>10kb) Multiome	557
chr19:12,774,659–12,776,025	170.4 kb	Distal (>10kb) Multiome	803
chr19:12,777,481–12,778,589	168.0 kb	Distal (>10kb) Multiome	661
chr19:12,782,418–12,783,038	163.1 kb	Distal (>10kb) Multiome	699
chr19:12,789,543–12,790,654	155.8 kb	Distal (>10kb) Multiome	717
chr19:12,790,960–12,793,231	154.3 kb	Distal (>10kb) Multiome	1015
chr19:12,793,340–12,794,240	152.2 kb	Distal (>10kb) Multiome	808
chr19:12,801,120–12,802,290	143.9 kb	Distal (>10kb) Multiome	901
chr19:12,806,212–12,806,984	139.3 kb	Distal (>10kb) Multiome	827
chr19:12,825,565–12,826,186	120.0 kb	Distal (>10kb) Multiome	436
chr19:12,832,484–12,833,101	113.2 kb	Distal (>10kb) Multiome	970
chr19:12,833,638–12,834,477	111.9 kb	Distal (>10kb) Multiome	310
chr19:12,838,114–12,838,869	107.4 kb	Distal (>10kb) Multiome	377
chr19:12,840,071–12,841,485	105.0 kb	Distal (>10kb) Multiome	391
chr19:12,847,633–12,848,090	98.1 kb	Distal (>10kb) Multiome	535
chr19:12,867,327–12,868,022	78.2 kb	Distal (>10kb) Multiome	315
chr19:12,872,968–12,873,990	72.5 kb	Distal (>10kb) Multiome	263
chr19:12,880,834–12,881,875	64.4 kb	Distal (>10kb) Multiome	656
chr19:12,884,836–12,886,381	60.5 kb	Distal (>10kb) Multiome	717
chr19:12,890,614–12,891,603	54.8 kb	Distal (>10kb) Multiome	841
chr19:12,913,054–12,913,584	32.5 kb	Distal (>10kb) Multiome	373
chr19:12,919,018–12,919,719	26.5 kb	Distal (>10kb) Multiome	732
chr19:12,933,441–12,934,086	12.1 kb	Distal (>10kb) Multiome	789
chr19:12,937,426–12,939,166	7.4 kb	Proximal (<10kb) Multiome	943
chr19:12,945,275–12,946,647	84 bp	At TSS Multiome	1015
chr19:12,956,801–12,957,360	11.4 kb	Distal (>10kb) Multiome	747
chr19:12,964,998–12,965,862	19.6 kb	Distal (>10kb) Multiome	733
chr19:12,983,506–12,983,997	37.8 kb	Distal (>10kb) Multiome	688
chr19:13,051,485–13,052,169	106.0 kb	Distal (>10kb) Multiome	649
chr19:13,061,195–13,061,672	115.6 kb	Distal (>10kb) Multiome	544
chr19:13,069,469–13,070,306	124.0 kb	Distal (>10kb) Multiome	334
chr19:13,093,620–13,094,260	148.1 kb	Distal (>10kb) Multiome	411
chr19:13,095,079–13,096,870	149.6 kb	Distal (>10kb) Multiome	501
chr19:13,102,495–13,103,074	157.0 kb	Distal (>10kb) Multiome	606
chr19:13,116,411–13,117,080	170.9 kb	Distal (>10kb) Multiome	812
chr19:13,117,979–13,119,416	172.4 kb	Distal (>10kb) Multiome	699
chr19:13,149,468–13,156,577	204.4 kb	Distal (>10kb) Multiome	1333
chr19:13,162,579–13,165,523	218.9 kb	Distal (>10kb) Multiome	1112
chr19:13,167,359–13,168,023	221.9 kb	Distal (>10kb) Multiome	764

Genome Browser

Genomic view of the RAD23A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.