This gene encodes a member of the Ras superfamily of small GTPases. The encoded protein binds to both GTP and GDP and may play a role in cell growth and survival. Overexpression of this gene may play a role in breast cancer tumorigenesis, and pseudogenes of this gene are located on the long arm of chromosome 2 and the short arm of chromosome 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for RABL6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RABL6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RABL6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:136,545,392–136,547,129 | 261.8 kb | Distal (>10kb) Multiome | 710 | |
| chr9:136,572,053–136,572,865 | 235.6 kb | Distal (>10kb) Multiome | 239 | |
| chr9:136,587,135–136,588,835 | 219.6 kb | Distal (>10kb) Multiome | 453 | |
| chr9:136,626,479–136,627,366 | 181.0 kb | Distal (>10kb) Multiome | 451 | |
| chr9:136,665,223–136,666,507 | 142.1 kb | Distal (>10kb) Multiome | 409 | |
| chr9:136,686,875–136,688,079 | 120.5 kb | Distal (>10kb) Multiome | 610 | |
| chr9:136,711,795–136,713,743 | 95.5 kb | Distal (>10kb) Multiome | 459 | |
| chr9:136,727,616–136,729,079 | 79.7 kb | Distal (>10kb) Multiome | 1013 | |
| chr9:136,762,846–136,763,902 | 44.7 kb | Distal (>10kb) Multiome | 271 | |
| chr9:136,788,889–136,789,680 | 18.6 kb | Distal (>10kb) Multiome | 351 | |
| chr9:136,790,433–136,792,285 | 16.9 kb | Distal (>10kb) Multiome | 864 | |
| chr9:136,798,823–136,801,421 | 6.6 kb | Proximal (<10kb) Multiome | 874 | |
| chr9:136,807,251–136,808,764 | 60 bp | At TSS Multiome | 714 | |
| chr9:136,842,325–136,842,872 | 34.6 kb | Distal (>10kb) Multiome | 492 | |
| chr9:136,846,187–136,850,214 | 41.5 kb | Distal (>10kb) Multiome | 1074 | |
| chr9:136,865,842–136,866,772 | 58.5 kb | Distal (>10kb) Multiome | 742 | |
| chr9:136,885,976–136,887,547 | 78.5 kb | Distal (>10kb) Multiome | 770 | |
| chr9:136,943,250–136,945,621 | 136.7 kb | Distal (>10kb) Multiome | 883 | |
| chr9:136,949,631–136,950,846 | 142.2 kb | Distal (>10kb) Multiome | 776 | |
| chr9:136,977,106–136,980,430 | 170.6 kb | Distal (>10kb) Multiome | 413 | |
| chr9:136,991,827–136,993,248 | 184.4 kb | Distal (>10kb) Multiome | 720 | |
| chr9:137,027,536–137,029,054 | 220.3 kb | Distal (>10kb) Multiome | 539 | |
| chr9:137,029,231–137,029,652 | 221.6 kb | Distal (>10kb) Multiome | 386 | |
| chr9:137,045,334–137,046,838 | 238.6 kb | Distal (>10kb) Multiome | 829 | |
| chr9:137,053,352–137,054,892 | 246.2 kb | Distal (>10kb) Multiome | 544 | |
| chr9:137,067,810–137,068,494 | 260.2 kb | Distal (>10kb) Multiome | 492 | |
| chr9:137,069,879–137,071,138 | 262.7 kb | Distal (>10kb) Multiome | 703 | |
| chr9:137,076,758–137,078,723 | 269.5 kb | Distal (>10kb) Multiome | 530 | |
| chr9:137,085,844–137,087,716 | 278.9 kb | Distal (>10kb) Multiome | 890 |
Genomic view of the RABL6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.