Transcription factors with Perturb-seq knockdown data for RABGAP1L-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RABGAP1L-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RABGAP1L-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:174,799,347–174,800,510 | 154.5 kb | Distal (>10kb) Multiome | 456 | |
| chr1:174,946,126–174,946,274 | 8.0 kb | Proximal (<10kb) | 30 | |
| chr1:174,953,794–174,953,961 | 299 bp | At TSS | 102 | |
| chr1:174,954,158–174,954,385 | at TSS | At TSS | 80 | |
| chr1:174,998,565–175,000,705 | 45.5 kb | Distal (>10kb) Multiome | 1242 | |
| chr1:175,022,930–175,024,023 | 69.3 kb | Distal (>10kb) Multiome | 878 | |
| chr1:175,029,423–175,030,223 | 75.6 kb | Distal (>10kb) Multiome | 562 | |
| chr1:175,073,610–175,074,084 | 119.6 kb | Distal (>10kb) Multiome | 76 | |
| chr1:175,129,648–175,130,843 | 176.0 kb | Distal (>10kb) Multiome | 246 | |
| chr1:175,146,568–175,147,254 | 192.5 kb | Distal (>10kb) Multiome | 324 | |
| chr1:175,151,904–175,152,560 | 198.0 kb | Distal (>10kb) Multiome | 185 | |
| chr1:175,191,731–175,193,773 | 238.7 kb | Distal (>10kb) Multiome | 565 |
Genomic view of the RABGAP1L-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.