Enables G protein activity; GDP binding activity; and GTP binding activity. Involved in positive regulation of exocytosis; receptor-mediated endocytosis; and regulation of protein localization. Located in late endosome; lysosome; and phagocytic vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RAB9A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB9A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB9A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:12,974,537–12,975,757 | 714.1 kb | Distal (>10kb) Multiome HiCAR | 603 | |
| chrX:13,652,915–13,653,709 | 35.9 kb | Distal (>10kb) Multiome | 692 | |
| chrX:13,688,926–13,689,830 | 38 bp | At TSS Multiome | 608 | |
| chrX:13,693,408–13,693,568 | 4.3 kb | Proximal (<10kb) | 76 | |
| chrX:13,734,289–13,735,335 | 45.6 kb | Distal (>10kb) Multiome | 668 | |
| chrX:13,937,416–13,939,477 | 249.4 kb | Distal (>10kb) Multiome | 380 |
Genomic view of the RAB9A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.