This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for RAB4A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB4A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB4A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:228,647,259–228,648,459 | 623.1 kb | Distal (>10kb) Multiome HiCAR | 684 | |
| chr1:229,027,699–229,028,244 | 243.0 kb | Distal (>10kb) Multiome | 280 | |
| chr1:229,090,571–229,091,190 | 180.3 kb | Distal (>10kb) Multiome | 31 | |
| chr1:229,093,644–229,094,437 | 177.1 kb | Distal (>10kb) Multiome | 253 | |
| chr1:229,203,285–229,203,797 | 67.5 kb | Distal (>10kb) Multiome | 237 | |
| chr1:229,270,652–229,271,643 | 46 bp | At TSS Multiome | 892 | |
| chr1:229,342,012–229,343,421 | 71.5 kb | Distal (>10kb) Multiome | 829 | |
| chr1:229,507,825–229,508,800 | 237.2 kb | Distal (>10kb) Multiome HiCAR | 885 | |
| chr1:229,557,924–229,559,481 | 287.8 kb | Distal (>10kb) Multiome | 985 |
Genomic view of the RAB4A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.