Enables GDP binding activity; GTP binding activity; and GTPase activity. Involved in several processes, including Golgi to plasma membrane protein transport; cellular response to insulin stimulus; and receptor internalization. Located in early endosome; phagocytic vesicle; and trans-Golgi network membrane. Biomarker of severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RAB31. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB31 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB31, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:9,474,512–9,476,246 | 232.9 kb | Distal (>10kb) Multiome | 971 | |
| chr18:9,495,937–9,496,497 | 212.1 kb | Distal (>10kb) Multiome | 78 | |
| chr18:9,613,721–9,615,403 | 93.4 kb | Distal (>10kb) Multiome | 740 | |
| chr18:9,700,207–9,700,899 | 7.8 kb | Proximal (<10kb) Multiome | 297 | |
| chr18:9,707,924–9,708,548 | 38 bp | At TSS Multiome | 464 | |
| chr18:9,876,800–9,877,632 | 169.1 kb | Distal (>10kb) Multiome | 502 | |
| chr18:9,913,270–9,915,160 | 205.6 kb | Distal (>10kb) Multiome | 983 |
Genomic view of the RAB31 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.