The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for RAB18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:27,240,222–27,241,262 | 263.6 kb | Distal (>10kb) Multiome | 831 | |
| chr10:27,241,284–27,242,441 | 262.1 kb | Distal (>10kb) Multiome | 851 | |
| chr10:27,252,226–27,253,021 | 251.6 kb | Distal (>10kb) Multiome | 405 | |
| chr10:27,258,839–27,259,511 | 245.1 kb | Distal (>10kb) Multiome | 220 | |
| chr10:27,319,712–27,320,433 | 184.2 kb | Distal (>10kb) Multiome | 239 | |
| chr10:27,460,714–27,461,433 | 43.2 kb | Distal (>10kb) Multiome | 40 | |
| chr10:27,465,047–27,465,926 | 38.7 kb | Distal (>10kb) Multiome | 128 | |
| chr10:27,503,674–27,504,967 | 4 bp | At TSS Multiome | 901 | |
| chr10:27,506,394–27,507,311 | 2.2 kb | Proximal (<10kb) | 25 | |
| chr10:27,741,179–27,743,908 | 238.1 kb | Distal (>10kb) Multiome | 543 | |
| chr10:27,744,907–27,746,641 | 241.6 kb | Distal (>10kb) Multiome | 361 |
Genomic view of the RAB18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.