The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009]
Transcription factors with Perturb-seq knockdown data for RAB17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:237,474,991–237,476,037 | 115.3 kb | Distal (>10kb) Multiome | 709 | |
| chr2:237,512,627–237,513,282 | 77.8 kb | Distal (>10kb) Multiome | 464 | |
| chr2:237,571,806–237,573,114 | 18.6 kb | Distal (>10kb) Multiome | 536 | |
| chr2:237,581,761–237,582,186 | 8.6 kb | Proximal (<10kb) | 303 | |
| chr2:237,591,030–237,591,195 | 250 bp | At TSS | 294 | |
| chr2:237,593,817–237,594,338 | 3.0 kb | Proximal (<10kb) | 108 | |
| chr2:237,594,513–237,595,741 | 4.3 kb | Proximal (<10kb) Multiome | 605 | |
| chr2:237,601,754–237,602,212 | 11.2 kb | Distal (>10kb) Multiome | 364 | |
| chr2:237,603,751–237,604,242 | 13.2 kb | Distal (>10kb) Multiome | 230 | |
| chr2:237,626,957–237,628,263 | 36.8 kb | Distal (>10kb) Multiome | 380 | |
| chr2:237,662,692–237,663,153 | 72.1 kb | Distal (>10kb) Multiome | 271 | |
| chr2:237,691,002–237,693,099 | 101.2 kb | Distal (>10kb) Multiome | 713 |
Genomic view of the RAB17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.