The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for RAB11FIP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB11FIP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB11FIP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:31,094,330–31,095,946 | 296.8 kb | Distal (>10kb) Multiome | 759 | |
| chr17:31,389,459–31,389,650 | 2.0 kb | Proximal (<10kb) | 129 | |
| chr17:31,391,064–31,392,079 | 40 bp | At TSS Multiome | 148 | |
| chr17:31,487,479–31,489,019 | 96.2 kb | Distal (>10kb) Multiome | 681 | |
| chr17:31,489,345–31,490,270 | 98.2 kb | Distal (>10kb) Multiome | 362 | |
| chr17:31,549,240–31,550,644 | 158.3 kb | Distal (>10kb) Multiome | 945 | |
| chr17:31,558,768–31,559,849 | 167.4 kb | Distal (>10kb) Multiome | 630 | |
| chr17:31,858,598–31,859,915 | 467.6 kb | Distal (>10kb) Multiome HiCAR | 554 |
Genomic view of the RAB11FIP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.