RAB11FIP3
RAB11 family interacting protein 3 | KIAA0665, Rab11-FIP3, eferin

Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008]

Member of: DE-8 DE-8.4 Developmental clusters: GC7
Biological processes 60 terms
Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)Golgi to plasma membrane protein transport (GO:0043001)bounding membrane of organelle (GO:0098588)calcium ion binding (GO:0005509)centrosome (GO:0005813)centrosome (GO:0005813)cleavage furrow (GO:0032154)cleavage furrow (GO:0032154)cleavage furrow (GO:0032154)cytoplasmic vesicle membrane (GO:0030659)cytosol (GO:0005829)dynein light intermediate chain binding (GO:0051959)dynein light intermediate chain binding (GO:0051959)endocytic recycling (GO:0032456)endocytic recycling (GO:0032456)endocytic recycling (GO:0032456)endocytic vesicle (GO:0030139)endocytic vesicle membrane (GO:0030666)endosome (GO:0005768)endosome membrane (GO:0010008)identical protein binding (GO:0042802)membrane (GO:0016020)midbody (GO:0030496)midbody (GO:0030496)midbody (GO:0030496)molecular adaptor activity (GO:0060090)molecular adaptor activity (GO:0060090)negative regulation of adiponectin secretion (GO:0070164)positive regulation of cilium assembly (GO:0045724)positive regulation of cilium assembly (GO:0045724)positive regulation of mitotic cytokinetic process (GO:1903438)postsynaptic recycling endosome membrane (GO:0098944)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein localization to cilium (GO:0061512)protein localization to cilium (GO:0061512)protein localization to cleavage furrow (GO:1905345)protein-macromolecule adaptor activity (GO:0030674)protein-macromolecule adaptor activity (GO:0030674)recycling endosome (GO:0055037)recycling endosome (GO:0055037)recycling endosome membrane (GO:0055038)recycling endosome membrane (GO:0055038)regulation of cilium assembly (GO:1902017)regulation of cilium assembly (GO:1902017)regulation of cytokinesis (GO:0032465)regulation of cytokinesis (GO:0032465)regulation of cytokinesis (GO:0032465)regulation of endocytic recycling (GO:2001135)regulation of protein localization to centrosome (GO:1904779)regulation of vesicle-mediated transport (GO:0060627)small GTPase binding (GO:0031267)small GTPase binding (GO:0031267)small GTPase binding (GO:0031267)small GTPase binding (GO:0031267)trans-Golgi network membrane (GO:0032588)vesicle-mediated transport (GO:0016192)vesicle-mediated transport (GO:0016192)
Expression (TPM)
RAB11FIP3 — as a Regulated Gene

TFs regulating RAB11FIP3 0 TFs

Transcription factors with Perturb-seq knockdown data for RAB11FIP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB11FIP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RAB11FIP3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB11FIP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr16:138,551–139,186 287.0 kb Distal (>10kb) Multiome 674
chr16:164,983–166,147 260.6 kb Distal (>10kb) Multiome 234
chr16:180,313–181,713 244.1 kb Distal (>10kb) Multiome 994
chr16:228,869–229,598 196.3 kb Distal (>10kb) Multiome 1035
chr16:234,152–235,669 190.8 kb Distal (>10kb) Multiome 908
chr16:351,804–354,436 72.7 kb Distal (>10kb) Multiome 654
chr16:378,999–379,813 46.3 kb Distal (>10kb) Multiome 225
chr16:380,836–382,614 43.7 kb Distal (>10kb) Multiome 634
chr16:383,438–384,218 41.8 kb Distal (>10kb) Multiome 342
chr16:396,893–397,640 28.2 kb Distal (>10kb) Multiome 496
chr16:401,380–402,199 23.8 kb Distal (>10kb) Multiome 818
chr16:424,888–426,136 64 bp At TSS Multiome 752
chr16:483,333–484,000 58.1 kb Distal (>10kb) Multiome 143
chr16:526,749–528,601 101.9 kb Distal (>10kb) Multiome 811
chr16:569,530–570,338 144.2 kb Distal (>10kb) Multiome 492
chr16:578,896–579,353 153.5 kb Distal (>10kb) Multiome 511
chr16:588,593–590,724 164.2 kb Distal (>10kb) Multiome 853
chr16:635,900–638,127 210.7 kb Distal (>10kb) Multiome 1021
chr16:641,491–643,007 216.2 kb Distal (>10kb) Multiome 856
chr16:648,795–649,829 223.7 kb Distal (>10kb) Multiome 862
chr16:660,457–661,656 235.3 kb Distal (>10kb) Multiome 456
chr16:667,633–668,442 242.4 kb Distal (>10kb) Multiome 838
chr16:678,847–681,585 254.4 kb Distal (>10kb) Multiome 803
chr16:683,618–684,859 258.8 kb Distal (>10kb) Multiome 701
chr16:694,897–695,485 269.8 kb Distal (>10kb) Multiome 390
chr16:705,242–706,468 280.3 kb Distal (>10kb) Multiome 248
chr16:714,577–716,048 289.4 kb Distal (>10kb) Multiome 555
chr16:720,434–721,963 295.7 kb Distal (>10kb) Multiome 966

Genome Browser

Genomic view of the RAB11FIP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr16:128,551 – 731,963
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact