RAB10

RAB10, member RAS oncogene family

RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]

Member of: DE-10 DE-10.3

Biological processes 68 terms

G protein activity (GO:0003925)G protein activity (GO:0003925)GDP binding (GO:0019003)GDP binding (GO:0019003)GTP binding (GO:0005525)GTP binding (GO:0005525)GTPase activity (GO:0003924)Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Golgi to plasma membrane protein transport (GO:0043001)Golgi to plasma membrane transport (GO:0006893)adherens junction (GO:0005912)antigen processing and presentation (GO:0019882)axonogenesis (GO:0007409)cadherin binding involved in cell-cell adhesion (GO:0098641)cell-cell adhesion (GO:0098609)cellular response to insulin stimulus (GO:0032869)cellular response to insulin stimulus (GO:0032869)cilium (GO:0005929)cilium (GO:0005929)cytoplasmic vesicle membrane (GO:0030659)cytoplasmic vesicle membrane (GO:0030659)cytosol (GO:0005829)endocytic recycling (GO:0032456)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum tubular network (GO:0071782)endoplasmic reticulum tubular network organization (GO:0071786)endosomal transport (GO:0016197)endosome (GO:0005768)endosome membrane (GO:0010008)endosome membrane (GO:0010008)establishment of neuroblast polarity (GO:0045200)establishment of protein localization to endoplasmic reticulum membrane (GO:0097051)establishment of protein localization to membrane (GO:0090150)exocyst (GO:0000145)exocytic vesicle (GO:0070382)exocytosis (GO:0006887)extracellular exosome (GO:0070062)focal adhesion (GO:0005925)insulin-responsive compartment (GO:0032593)lysosome (GO:0005764)membrane (GO:0016020)myosin V binding (GO:0031489)myosin V binding (GO:0031489)negative regulation of motile cilium assembly (GO:1905504)perinuclear region of cytoplasm (GO:0048471)perinuclear region of cytoplasm (GO:0048471)phagocytic vesicle membrane (GO:0030670)plasma membrane (GO:0005886)plasma membrane (GO:0005886)polarized epithelial cell differentiation (GO:0030859)protein binding (GO:0005515)protein localization to basolateral plasma membrane (GO:1903361)protein localization to plasma membrane (GO:0072659)protein localization to plasma membrane (GO:0072659)recycling endosome (GO:0055037)recycling endosome (GO:0055037)recycling endosome (GO:0055037)recycling endosome membrane (GO:0055038)regulated exocytosis (GO:0045055)secretory granule membrane (GO:0030667)secretory vesicle (GO:0099503)trans-Golgi network (GO:0005802)vesicle-mediated transport (GO:0016192)vesicle-mediated transport (GO:0016192)

Expression (TPM)

TFs regulating RAB10 0 TFs

Transcription factors with Perturb-seq knockdown data for RAB10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RAB10

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:25,877,423–25,878,991	155.5 kb	Distal (>10kb) Multiome	984
chr2:25,912,966–25,913,435	120.8 kb	Distal (>10kb) Multiome	140
chr2:25,981,827–25,983,286	51.5 kb	Distal (>10kb) Multiome	664
chr2:26,011,658–26,012,446	22.0 kb	Distal (>10kb) Multiome	485
chr2:26,033,136–26,034,956	178 bp	At TSS Multiome	1165
chr2:26,172,352–26,174,365	138.9 kb	Distal (>10kb) Multiome	420
chr2:26,178,689–26,179,345	145.0 kb	Distal (>10kb) Multiome	245
chr2:26,179,469–26,180,030	145.7 kb	Distal (>10kb) Multiome	122
chr2:26,184,159–26,185,510	150.8 kb	Distal (>10kb) Multiome	494
chr2:26,202,471–26,204,141	169.7 kb	Distal (>10kb) Multiome	38
chr2:26,244,319–26,245,633	210.7 kb	Distal (>10kb) Multiome	928

Genome Browser

Genomic view of the RAB10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.