Contributes to glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Located in mitochondrion. Part of glutamyl-tRNA(Gln) amidotransferase complex. Implicated in combined oxidative phosphorylation deficiency 40. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for QRSL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = QRSL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of QRSL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:106,360,205–106,361,449 | 269.0 kb | Distal (>10kb) Multiome | 616 | |
| chr6:106,422,406–106,423,164 | 206.7 kb | Distal (>10kb) Multiome | 102 | |
| chr6:106,511,736–106,513,208 | 117.1 kb | Distal (>10kb) Multiome | 661 | |
| chr6:106,629,212–106,630,045 | 14 bp | At TSS Multiome | 661 | |
| chr6:106,973,315–106,975,918 | 345.4 kb | Distal (>10kb) Multiome HiCAR | 630 |
Genomic view of the QRSL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.