Predicted to enable several functions, including histone acetyltransferase regulator activity; histone binding activity; and zinc ion binding activity. Predicted to be involved in kidney development and spermatid nucleus differentiation. Predicted to act upstream of or within several processes, including canonical Wnt signaling pathway; lens development in camera-type eye; and regulation of mammary gland epithelial cell proliferation. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PYGO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PYGO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PYGO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:154,683,607–154,684,346 | 277.8 kb | Distal (>10kb) Multiome | 39 | |
| chr1:154,760,465–154,760,941 | 201.1 kb | Distal (>10kb) Multiome | 418 | |
| chr1:154,813,354–154,814,052 | 148.2 kb | Distal (>10kb) Multiome | 189 | |
| chr1:154,870,031–154,870,680 | 91.4 kb | Distal (>10kb) Multiome | 300 | |
| chr1:154,936,148–154,937,752 | 24.8 kb | Distal (>10kb) Multiome | 1149 | |
| chr1:154,955,571–154,956,925 | 5.6 kb | Proximal (<10kb) Multiome | 504 | |
| chr1:154,961,269–154,962,529 | 40 bp | At TSS Multiome | 985 | |
| chr1:154,970,161–154,971,641 | 9.1 kb | Proximal (<10kb) Multiome | 535 | |
| chr1:154,972,362–154,975,914 | 12.8 kb | Distal (>10kb) Multiome | 1085 | |
| chr1:154,982,968–154,983,632 | 21.4 kb | Distal (>10kb) Multiome | 693 | |
| chr1:154,998,961–155,004,423 | 37.5 kb | Distal (>10kb) Multiome | 1210 | |
| chr1:155,017,084–155,017,941 | 55.7 kb | Distal (>10kb) Multiome | 1003 | |
| chr1:155,050,292–155,052,078 | 89.5 kb | Distal (>10kb) Multiome | 948 | |
| chr1:155,061,415–155,064,552 | 102.1 kb | Distal (>10kb) Multiome | 860 | |
| chr1:155,070,748–155,071,423 | 109.3 kb | Distal (>10kb) Multiome | 542 | |
| chr1:155,078,524–155,079,535 | 117.0 kb | Distal (>10kb) Multiome | 397 | |
| chr1:155,079,852–155,081,529 | 119.2 kb | Distal (>10kb) Multiome | 539 | |
| chr1:155,084,373–155,086,501 | 123.3 kb | Distal (>10kb) Multiome | 865 | |
| chr1:155,091,315–155,091,900 | 129.8 kb | Distal (>10kb) Multiome | 594 | |
| chr1:155,126,247–155,126,903 | 164.7 kb | Distal (>10kb) Multiome | 776 | |
| chr1:155,127,607–155,128,120 | 166.1 kb | Distal (>10kb) Multiome | 578 | |
| chr1:155,135,100–155,136,750 | 174.1 kb | Distal (>10kb) Multiome | 938 | |
| chr1:155,166,847–155,168,170 | 206.0 kb | Distal (>10kb) Multiome | 622 | |
| chr1:155,172,629–155,174,979 | 211.5 kb | Distal (>10kb) Multiome | 903 | |
| chr1:155,192,921–155,194,099 | 231.8 kb | Distal (>10kb) Multiome | 755 | |
| chr1:155,194,230–155,195,403 | 233.1 kb | Distal (>10kb) Multiome | 753 | |
| chr1:155,196,127–155,196,592 | 234.6 kb | Distal (>10kb) Multiome | 97 | |
| chr1:155,207,822–155,209,789 | 247.2 kb | Distal (>10kb) Multiome | 826 | |
| chr1:155,226,522–155,227,197 | 264.8 kb | Distal (>10kb) Multiome | 600 | |
| chr1:155,227,312–155,228,116 | 265.9 kb | Distal (>10kb) Multiome | 688 | |
| chr1:155,244,103–155,245,349 | 283.0 kb | Distal (>10kb) Multiome | 900 | |
| chr1:155,250,356–155,251,199 | 289.1 kb | Distal (>10kb) Multiome | 605 | |
| chr1:155,255,032–155,255,921 | 293.8 kb | Distal (>10kb) Multiome | 661 |
Genomic view of the PYGO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.