Enables methylated histone binding activity. Predicted to be involved in kidney development and spermatid nucleus differentiation. Predicted to act upstream of or within several processes, including hematopoietic progenitor cell differentiation; positive regulation of transcription by RNA polymerase II; and spermatid development. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PYGO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PYGO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PYGO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:55,288,999–55,291,001 | 297.9 kb | Distal (>10kb) Multiome | 744 | |
| chr15:55,318,855–55,319,494 | 269.2 kb | Distal (>10kb) Multiome | 875 | |
| chr15:55,407,568–55,409,007 | 180.0 kb | Distal (>10kb) Multiome | 957 | |
| chr15:55,498,088–55,498,593 | 89.9 kb | Distal (>10kb) Multiome | 637 | |
| chr15:55,581,323–55,581,979 | 6.4 kb | Proximal (<10kb) | 16 | |
| chr15:55,587,537–55,588,889 | 92 bp | At TSS Multiome | 432 | |
| chr15:55,741,161–55,743,756 | 154.9 kb | Distal (>10kb) Multiome | 809 |
Genomic view of the PYGO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.