This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Transcription factors with Perturb-seq knockdown data for PXK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PXK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PXK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:58,034,682–58,035,269 | 297.9 kb | Distal (>10kb) Multiome | 260 | |
| chr3:58,049,229–58,049,752 | 283.5 kb | Distal (>10kb) Multiome | 668 | |
| chr3:58,177,450–58,178,460 | 154.9 kb | Distal (>10kb) Multiome | 551 | |
| chr3:58,187,606–58,188,058 | 145.0 kb | Distal (>10kb) Multiome | 377 | |
| chr3:58,217,189–58,217,783 | 115.5 kb | Distal (>10kb) Multiome | 545 | |
| chr3:58,222,267–58,222,780 | 110.4 kb | Distal (>10kb) Multiome | 115 | |
| chr3:58,236,918–58,238,686 | 95.3 kb | Distal (>10kb) Multiome | 727 | |
| chr3:58,305,855–58,306,746 | 26.6 kb | Distal (>10kb) Multiome | 875 | |
| chr3:58,332,558–58,333,709 | 18 bp | At TSS Multiome | 705 | |
| chr3:58,433,383–58,434,404 | 101.0 kb | Distal (>10kb) Multiome | 938 | |
| chr3:58,434,510–58,435,588 | 102.3 kb | Distal (>10kb) Multiome | 226 | |
| chr3:58,441,570–58,442,309 | 109.1 kb | Distal (>10kb) Multiome | 65 | |
| chr3:58,450,170–58,450,919 | 117.7 kb | Distal (>10kb) Multiome | 20 | |
| chr3:58,463,546–58,463,974 | 130.9 kb | Distal (>10kb) Multiome | 479 | |
| chr3:58,470,966–58,471,873 | 138.6 kb | Distal (>10kb) Multiome | 742 | |
| chr3:58,491,060–58,492,581 | 159.1 kb | Distal (>10kb) Multiome | 631 | |
| chr3:58,585,026–58,585,766 | 252.6 kb | Distal (>10kb) Multiome | 401 | |
| chr3:58,586,723–58,587,275 | 254.2 kb | Distal (>10kb) Multiome | 131 | |
| chr3:58,629,982–58,630,563 | 297.4 kb | Distal (>10kb) Multiome | 197 |
Genomic view of the PXK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.