Predicted to enable pseudouridine synthase activity. Predicted to be involved in tRNA pseudouridine synthesis. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PUSL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PUSL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PUSL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:1,019,142–1,021,414 | 289.0 kb | Distal (>10kb) Multiome | 707 | |
| chr1:1,032,438–1,034,753 | 275.4 kb | Distal (>10kb) Multiome | 475 | |
| chr1:1,040,071–1,041,597 | 267.6 kb | Distal (>10kb) Multiome | 410 | |
| chr1:1,058,856–1,060,114 | 249.0 kb | Distal (>10kb) Multiome | 609 | |
| chr1:1,068,556–1,069,991 | 239.4 kb | Distal (>10kb) Multiome | 577 | |
| chr1:1,079,478–1,080,558 | 228.5 kb | Distal (>10kb) Multiome | 746 | |
| chr1:1,115,769–1,117,022 | 192.4 kb | Distal (>10kb) Multiome | 743 | |
| chr1:1,157,424–1,158,362 | 151.0 kb | Distal (>10kb) Multiome | 575 | |
| chr1:1,231,448–1,233,390 | 76.5 kb | Distal (>10kb) Multiome | 884 | |
| chr1:1,273,333–1,274,645 | 34.6 kb | Distal (>10kb) Multiome | 779 | |
| chr1:1,293,434–1,294,454 | 14.7 kb | Distal (>10kb) Multiome | 234 | |
| chr1:1,304,741–1,305,201 | 3.4 kb | Proximal (<10kb) | 469 | |
| chr1:1,305,632–1,305,871 | 2.7 kb | Proximal (<10kb) | 385 | |
| chr1:1,307,375–1,310,219 | 330 bp | At TSS Multiome | 897 | |
| chr1:1,324,278–1,325,394 | 16.2 kb | Distal (>10kb) Multiome | 735 | |
| chr1:1,348,716–1,350,027 | 40.9 kb | Distal (>10kb) Multiome HiCAR | 539 | |
| chr1:1,353,403–1,354,425 | 45.3 kb | Distal (>10kb) Multiome | 276 | |
| chr1:1,374,767–1,375,798 | 66.8 kb | Distal (>10kb) Multiome | 1113 | |
| chr1:1,398,861–1,399,955 | 90.9 kb | Distal (>10kb) Multiome | 879 | |
| chr1:1,406,992–1,407,823 | 98.7 kb | Distal (>10kb) Multiome | 938 | |
| chr1:1,435,318–1,436,066 | 127.1 kb | Distal (>10kb) Multiome | 511 | |
| chr1:1,511,442–1,512,404 | 203.4 kb | Distal (>10kb) Multiome | 897 | |
| chr1:1,540,164–1,541,317 | 232.0 kb | Distal (>10kb) Multiome | 195 | |
| chr1:1,573,904–1,575,432 | 266.2 kb | Distal (>10kb) Multiome | 949 | |
| chr1:1,599,945–1,600,642 | 291.5 kb | Distal (>10kb) Multiome | 307 |
Genomic view of the PUSL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.