Enables enzyme binding activity and tRNA pseudouridine(13) synthase activity. Involved in several processes, including pseudouridine synthesis; regulation of hematopoietic stem cell differentiation; and regulation of mesoderm development. Is active in nucleus. Implicated in intellectual developmental disorder with abnormal behavior, microcephaly, and short stature. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PUS7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PUS7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PUS7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:105,350,605–105,351,448 | 171.2 kb | Distal (>10kb) Multiome | 116 | |
| chr7:105,387,785–105,389,508 | 133.3 kb | Distal (>10kb) Multiome | 725 | |
| chr7:105,521,330–105,522,854 | 92 bp | At TSS Multiome | 900 | |
| chr7:105,531,803–105,532,700 | 9.9 kb | Proximal (<10kb) Multiome | 946 | |
| chr7:105,580,977–105,581,814 | 59.2 kb | Distal (>10kb) Multiome | 492 | |
| chr7:105,638,494–105,639,567 | 117.0 kb | Distal (>10kb) Multiome | 209 | |
| chr7:105,643,274–105,643,732 | 121.3 kb | Distal (>10kb) Multiome | 211 | |
| chr7:105,651,976–105,652,948 | 130.3 kb | Distal (>10kb) Multiome | 292 | |
| chr7:105,655,354–105,656,152 | 133.5 kb | Distal (>10kb) Multiome | 203 | |
| chr7:105,657,015–105,657,727 | 135.0 kb | Distal (>10kb) Multiome | 205 | |
| chr7:105,664,641–105,665,449 | 142.8 kb | Distal (>10kb) Multiome | 422 | |
| chr7:105,689,008–105,690,124 | 167.2 kb | Distal (>10kb) Multiome | 195 | |
| chr7:105,695,816–105,698,274 | 175.0 kb | Distal (>10kb) Multiome | 292 |
Genomic view of the PUS7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.