Enables RNA binding activity. Predicted to be involved in regulation of translation. Located in chromosome; endoplasmic reticulum; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PUM3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PUM3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PUM3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:2,280,841–2,282,179 | 562.7 kb | Distal (>10kb) Multiome HiCAR | 259 | |
| chr9:2,283,300–2,283,939 | 560.5 kb | Distal (>10kb) Multiome HiCAR | 77 | |
| chr9:2,620,982–2,623,801 | 222.5 kb | Distal (>10kb) Multiome | 768 | |
| chr9:2,745,497–2,746,547 | 98.3 kb | Distal (>10kb) Multiome | 205 | |
| chr9:2,764,803–2,765,871 | 78.8 kb | Distal (>10kb) Multiome | 210 | |
| chr9:2,770,773–2,771,918 | 72.9 kb | Distal (>10kb) Multiome | 272 | |
| chr9:2,816,339–2,817,126 | 27.4 kb | Distal (>10kb) Multiome | 152 | |
| chr9:2,843,166–2,844,741 | 77 bp | At TSS Multiome | 860 | |
| chr9:4,661,662–4,663,256 | 1818.2 kb | Distal (>10kb) Multiome HiCAR | 925 |
Genomic view of the PUM3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.