The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
Transcription factors with Perturb-seq knockdown data for PTPN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTPN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTPN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:12,657,070–12,658,817 | 225.7 kb | Distal (>10kb) Multiome | 689 | |
| chr18:12,702,219–12,703,287 | 181.0 kb | Distal (>10kb) Multiome | 869 | |
| chr18:12,766,645–12,767,371 | 116.7 kb | Distal (>10kb) Multiome | 392 | |
| chr18:12,776,564–12,778,096 | 106.8 kb | Distal (>10kb) Multiome | 123 | |
| chr18:12,862,247–12,862,768 | 21.2 kb | Distal (>10kb) Multiome | 116 | |
| chr18:12,883,233–12,884,627 | 337 bp | At TSS Multiome | 904 | |
| chr18:12,885,337–12,885,992 | 1.5 kb | Proximal (<10kb) | 167 | |
| chr18:12,946,945–12,948,745 | 64.1 kb | Distal (>10kb) Multiome | 1139 | |
| chr18:12,989,036–12,990,533 | 105.6 kb | Distal (>10kb) Multiome | 336 | |
| chr18:12,990,680–12,991,971 | 107.5 kb | Distal (>10kb) Multiome | 977 | |
| chr18:13,003,392–13,003,928 | 119.8 kb | Distal (>10kb) Multiome | 168 |
Genomic view of the PTPN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.