PTMA

prothymosin alpha | TMSA

Enables DNA-binding transcription factor binding activity and histone binding activity. Involved in negative regulation of apoptotic process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1 DE-1.7 Developmental clusters: GC4

Biological processes 18 terms

DNA-binding transcription factor binding (GO:0140297)DNA-templated transcription (GO:0006351)calcium ion binding (GO:0005509)chromatin organization (GO:0006325)cytosol (GO:0005829)histone binding (GO:0042393)histone binding (GO:0042393)histone binding (GO:0042393)histone chaperone activity (GO:0140713)negative regulation of apoptotic process (GO:0043066)negative regulation of apoptotic process (GO:0043066)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)

Expression (TPM)

TFs regulating PTMA 0 TFs

Transcription factors with Perturb-seq knockdown data for PTMA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTMA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PTMA

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTMA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:231,410,617–231,411,062	296.9 kb	Distal (>10kb) Multiome	150
chr2:231,411,845–231,413,014	295.3 kb	Distal (>10kb) Multiome	691
chr2:231,463,695–231,465,687	243.0 kb	Distal (>10kb) Multiome	1126
chr2:231,482,645–231,483,215	224.7 kb	Distal (>10kb) Multiome	450
chr2:231,483,468–231,484,163	223.7 kb	Distal (>10kb) Multiome	197
chr2:231,514,074–231,514,984	193.1 kb	Distal (>10kb) Multiome	731
chr2:231,530,197–231,530,963	177.1 kb	Distal (>10kb) Multiome	395
chr2:231,557,621–231,558,377	149.6 kb	Distal (>10kb) Multiome	215
chr2:231,601,487–231,602,111	105.8 kb	Distal (>10kb) Multiome	239
chr2:231,604,056–231,605,408	102.8 kb	Distal (>10kb) Multiome	677
chr2:231,611,822–231,613,019	95.0 kb	Distal (>10kb) Multiome	673
chr2:231,613,128–231,615,041	93.4 kb	Distal (>10kb) Multiome	956
chr2:231,621,037–231,621,485	86.2 kb	Distal (>10kb) Multiome	189
chr2:231,661,829–231,663,079	45.3 kb	Distal (>10kb) Multiome	645
chr2:231,666,093–231,667,175	41.1 kb	Distal (>10kb) Multiome	778
chr2:231,672,732–231,673,910	34.2 kb	Distal (>10kb) Multiome	570
chr2:231,674,697–231,675,325	32.6 kb	Distal (>10kb) Multiome	455
chr2:231,679,801–231,681,869	26.5 kb	Distal (>10kb) Multiome	959
chr2:231,687,250–231,687,863	20.2 kb	Distal (>10kb) Multiome	640
chr2:231,706,062–231,711,186	723 bp	At TSS Multiome	1322
chr2:231,713,567–231,715,698	7.7 kb	Proximal (<10kb) Multiome	974
chr2:231,716,187–231,716,634	9.3 kb	Proximal (<10kb)	111
chr2:231,780,605–231,781,892	73.8 kb	Distal (>10kb) Multiome	832
chr2:231,786,115–231,787,127	78.9 kb	Distal (>10kb) Multiome	1074
chr2:231,924,925–231,927,159	217.7 kb	Distal (>10kb) Multiome	655
chr2:231,961,157–231,962,183	254.0 kb	Distal (>10kb) Multiome	981

Genome Browser

Genomic view of the PTMA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.