PTH2R

parathyroid hormone 2 receptor | PTHR2

The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Biological processes 17 terms

G protein-coupled peptide receptor activity (GO:0008528)G protein-coupled receptor activity (GO:0004930)G protein-coupled receptor signaling pathway (GO:0007186)G protein-coupled receptor signaling pathway (GO:0007186)adenylate cyclase-modulating G protein-coupled receptor signaling pathway (GO:0007188)cell surface receptor signaling pathway (GO:0007166)membrane (GO:0016020)parathyroid hormone receptor activity (GO:0004991)parathyroid hormone receptor activity (GO:0004991)peptide hormone binding (GO:0017046)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of cold-induced thermogenesis (GO:0120162)positive regulation of cold-induced thermogenesis (GO:0120162)protein binding (GO:0005515)transmembrane signaling receptor activity (GO:0004888)

Expression (TPM)

TFs regulating PTH2R 0 TFs

Transcription factors with Perturb-seq knockdown data for PTH2R. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTH2R upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PTH2R

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTH2R, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:208,112,378–208,113,769	246.5 kb	Distal (>10kb) Multiome	285
chr2:208,124,049–208,124,760	235.3 kb	Distal (>10kb) Multiome	140
chr2:208,142,720–208,143,849	216.3 kb	Distal (>10kb) Multiome	333
chr2:208,215,744–208,216,551	143.6 kb	Distal (>10kb) Multiome	25
chr2:208,253,738–208,255,989	105.5 kb	Distal (>10kb) Multiome	1085
chr2:208,265,281–208,266,835	93.5 kb	Distal (>10kb) Multiome	1005
chr2:208,267,505–208,268,088	91.9 kb	Distal (>10kb) Multiome	169
chr2:208,317,884–208,318,936	41.4 kb	Distal (>10kb) Multiome	106
chr2:208,406,386–208,407,453	47.2 kb	Distal (>10kb) Multiome	324
chr2:208,407,782–208,407,954	991 bp	At TSS	64
chr2:208,638,022–208,638,665	278.5 kb	Distal (>10kb) Multiome	304
chr2:209,208,033–209,210,222	849.6 kb	Distal (>10kb) Multiome HiCAR	321
chr2:209,298,652–209,299,936	939.9 kb	Distal (>10kb) Multiome HiCAR	105
chr2:209,305,077–209,308,685	948.0 kb	Distal (>10kb) Multiome HiCAR	373
chr2:209,423,435–209,424,894	1064.2 kb	Distal (>10kb) Multiome HiCAR	597
chr2:209,614,729–209,616,012	1255.5 kb	Distal (>10kb) Multiome HiCAR	309
chr2:209,960,058–209,961,333	1601.3 kb	Distal (>10kb) Multiome HiCAR	269
chr2:209,985,387–209,986,656	1626.1 kb	Distal (>10kb) Multiome HiCAR	197
chr2:210,224,566–210,225,799	1865.4 kb	Distal (>10kb) Multiome HiCAR	493

Genome Browser

Genomic view of the PTH2R locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.