Enables RNA binding activity. Predicted to be involved in mitochondrion organization and regulation of mRNA processing. Predicted to act upstream of or within several processes, including liver development; muscle cell development; and ventricular cardiac muscle tissue morphogenesis. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PTCD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTCD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTCD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:72,057,600–72,058,552 | 262.3 kb | Distal (>10kb) Multiome | 65 | |
| chr5:72,065,796–72,066,276 | 254.3 kb | Distal (>10kb) Multiome | 107 | |
| chr5:72,106,794–72,109,078 | 211.6 kb | Distal (>10kb) Multiome | 816 | |
| chr5:72,307,892–72,308,896 | 12.0 kb | Distal (>10kb) Multiome | 956 | |
| chr5:72,319,763–72,320,908 | 37 bp | At TSS Multiome | 876 | |
| chr5:72,541,250–72,542,235 | 221.4 kb | Distal (>10kb) Multiome | 116 | |
| chr5:72,556,396–72,557,392 | 236.6 kb | Distal (>10kb) Multiome | 362 |
Genomic view of the PTCD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.