The protein encoded by this gene binds RNA and is a regulator of cell differentiation. The encoded protein preferentially binds to poly(G) and poly(U) sequences in vitro. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for PTBP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTBP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTBP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:112,065,640–112,066,613 | 267.6 kb | Distal (>10kb) Multiome | 338 | |
| chr9:112,097,640–112,098,616 | 235.6 kb | Distal (>10kb) Multiome HiCAR | 337 | |
| chr9:112,174,728–112,175,784 | 158.5 kb | Distal (>10kb) Multiome | 620 | |
| chr9:112,332,780–112,334,661 | 145 bp | At TSS Multiome | 913 | |
| chr9:112,379,308–112,380,565 | 46.3 kb | Distal (>10kb) Multiome | 895 | |
| chr9:112,486,079–112,487,780 | 153.2 kb | Distal (>10kb) Multiome | 1004 |
Genomic view of the PTBP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.