Predicted to be located in cytoskeleton; cytosol; and membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PSTPIP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSTPIP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSTPIP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:45,828,904–45,829,753 | 242.9 kb | Distal (>10kb) Multiome | 246 | |
| chr18:45,837,425–45,838,195 | 234.5 kb | Distal (>10kb) Multiome | 298 | |
| chr18:45,966,885–45,967,828 | 104.9 kb | Distal (>10kb) Multiome HiCAR | 738 | |
| chr18:46,071,357–46,072,732 | 3 bp | At TSS Multiome | 481 | |
| chr18:46,073,657–46,074,233 | 1.4 kb | Proximal (<10kb) | 176 | |
| chr18:46,088,381–46,089,449 | 16.5 kb | Distal (>10kb) Multiome | 165 | |
| chr18:46,097,820–46,098,847 | 26.1 kb | Distal (>10kb) Multiome | 879 | |
| chr18:46,104,121–46,104,853 | 32.1 kb | Distal (>10kb) Multiome | 704 | |
| chr18:46,173,230–46,174,989 | 101.5 kb | Distal (>10kb) Multiome | 936 | |
| chr18:46,246,205–46,246,709 | 174.2 kb | Distal (>10kb) Multiome | 36 | |
| chr18:46,281,044–46,282,187 | 209.2 kb | Distal (>10kb) Multiome | 176 | |
| chr18:46,283,349–46,284,427 | 211.7 kb | Distal (>10kb) Multiome | 234 | |
| chr18:46,333,344–46,334,272 | 261.7 kb | Distal (>10kb) Multiome | 327 | |
| chr18:46,335,534–46,336,092 | 263.4 kb | Distal (>10kb) Multiome | 192 |
Genomic view of the PSTPIP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.