The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PSPH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSPH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSPH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:55,886,966–55,887,754 | 164.0 kb | Distal (>10kb) Multiome | 546 | |
| chr7:55,951,547–55,952,549 | 99.6 kb | Distal (>10kb) Multiome | 801 | |
| chr7:55,964,099–55,965,278 | 86.8 kb | Distal (>10kb) Multiome | 738 | |
| chr7:56,033,660–56,034,707 | 17.2 kb | Distal (>10kb) Multiome | 673 | |
| chr7:56,046,708–56,047,402 | 4.0 kb | Proximal (<10kb) | 118 | |
| chr7:56,051,159–56,052,300 | 190 bp | At TSS Multiome | 882 | |
| chr7:56,063,656–56,065,393 | 12.8 kb | Distal (>10kb) Multiome | 926 | |
| chr7:56,074,109–56,074,780 | 23.0 kb | Distal (>10kb) Multiome | 423 | |
| chr7:56,106,168–56,106,786 | 55.1 kb | Distal (>10kb) Multiome | 866 |
Genomic view of the PSPH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.