The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S proteasome assembly. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for PSMD5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMD5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMD5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:120,579,589–120,580,675 | 262.7 kb | Distal (>10kb) Multiome | 900 | |
| chr9:120,713,676–120,715,795 | 128.3 kb | Distal (>10kb) Multiome | 761 | |
| chr9:120,730,681–120,731,453 | 111.9 kb | Distal (>10kb) Multiome | 456 | |
| chr9:120,792,955–120,793,917 | 49.5 kb | Distal (>10kb) Multiome HiCAR | 991 | |
| chr9:120,842,458–120,843,456 | 100 bp | At TSS Multiome | 838 | |
| chr9:120,868,216–120,869,551 | 26.0 kb | Distal (>10kb) Multiome | 643 | |
| chr9:120,873,261–120,874,043 | 30.7 kb | Distal (>10kb) Multiome | 247 | |
| chr9:120,875,854–120,877,760 | 33.4 kb | Distal (>10kb) Multiome | 982 | |
| chr9:120,928,372–120,929,413 | 86.1 kb | Distal (>10kb) Multiome | 626 | |
| chr9:121,074,349–121,075,511 | 232.1 kb | Distal (>10kb) Multiome | 1041 | |
| chr9:121,121,551–121,122,082 | 278.8 kb | Distal (>10kb) Multiome | 539 |
Genomic view of the PSMD5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.