The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PSMD13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMD13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMD13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:206,950–208,051 | 29.5 kb | Distal (>10kb) Multiome | 884 | |
| chr11:208,471–209,205 | 28.1 kb | Distal (>10kb) Multiome | 593 | |
| chr11:235,864–237,255 | 491 bp | At TSS Multiome | 874 | |
| chr11:288,466–289,320 | 52.1 kb | Distal (>10kb) Multiome | 400 | |
| chr11:313,383–314,476 | 76.9 kb | Distal (>10kb) Multiome | 421 | |
| chr11:316,978–318,064 | 80.2 kb | Distal (>10kb) Multiome | 100 | |
| chr11:333,722–334,610 | 97.3 kb | Distal (>10kb) Multiome | 238 | |
| chr11:355,654–356,479 | 119.2 kb | Distal (>10kb) Multiome | 894 | |
| chr11:370,037–370,556 | 133.2 kb | Distal (>10kb) Multiome | 205 | |
| chr11:406,008–408,661 | 170.3 kb | Distal (>10kb) Multiome | 587 | |
| chr11:416,764–417,613 | 180.4 kb | Distal (>10kb) Multiome | 431 | |
| chr11:447,919–448,752 | 211.3 kb | Distal (>10kb) Multiome | 808 | |
| chr11:449,838–451,194 | 213.3 kb | Distal (>10kb) Multiome | 836 | |
| chr11:506,153–507,989 | 270.2 kb | Distal (>10kb) Multiome | 977 | |
| chr11:534,525–536,399 | 298.7 kb | Distal (>10kb) Multiome | 673 |
Genomic view of the PSMD13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.