The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PSMC6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMC6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMC6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:52,551,688–52,554,284 | 154.5 kb | Distal (>10kb) Multiome | 899 | |
| chr14:52,694,713–52,696,105 | 11.4 kb | Distal (>10kb) Multiome | 749 | |
| chr14:52,706,745–52,707,707 | 47 bp | At TSS Multiome | 713 | |
| chr14:52,729,614–52,730,927 | 22.9 kb | Distal (>10kb) Multiome | 803 | |
| chr14:52,790,881–52,792,384 | 84.5 kb | Distal (>10kb) Multiome | 1077 | |
| chr14:52,827,263–52,828,172 | 120.4 kb | Distal (>10kb) Multiome | 103 | |
| chr14:52,835,079–52,835,883 | 128.2 kb | Distal (>10kb) Multiome | 369 | |
| chr14:52,852,332–52,854,201 | 146.1 kb | Distal (>10kb) Multiome | 475 | |
| chr14:52,950,305–52,952,252 | 244.0 kb | Distal (>10kb) Multiome | 746 |
Genomic view of the PSMC6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.