The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for PSMB7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMB7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMB7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:124,257,674–124,258,314 | 157.4 kb | Distal (>10kb) Multiome | 374 | |
| chr9:124,415,161–124,415,813 | 34 bp | At TSS Multiome | 779 | |
| chr9:124,419,615–124,420,013 | 4.2 kb | Proximal (<10kb) Multiome | 266 | |
| chr9:124,449,997–124,450,901 | 35.0 kb | Distal (>10kb) Multiome | 232 | |
| chr9:124,453,124–124,454,077 | 38.2 kb | Distal (>10kb) Multiome | 218 | |
| chr9:124,477,322–124,478,654 | 62.5 kb | Distal (>10kb) Multiome | 223 | |
| chr9:124,482,335–124,482,814 | 67.2 kb | Distal (>10kb) Multiome | 94 | |
| chr9:124,504,291–124,505,297 | 89.6 kb | Distal (>10kb) Multiome | 187 |
Genomic view of the PSMB7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.