PSMB3

proteasome 20S subunit beta 3 | HC10-II, MGC4147

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants [provided by RefSeq, Sep 2013]

Member of: DE-1 DE-1.35 Developmental clusters: GC5 GC5

Biological processes 56 terms

CD8-positive, alpha-beta T cell differentiation (GO:0043374)CD8-positive, alpha-beta T cell homeostasis (GO:0160165)DNA damage response (GO:0006974)DNA repair (GO:0006281)T-helper 1 cell differentiation (GO:0045063)T-helper 17 cell differentiation (GO:0072539)apoptotic process (GO:0006915)cellular response to type I interferon (GO:0071357)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)extracellular exosome (GO:0070062)flagellated sperm motility (GO:0030317)immune system process (GO:0002376)meiotic cell cycle (GO:0051321)negative regulation of regulatory T cell differentiation (GO:0045590)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of interleukin-2 production (GO:0032743)positive regulation of tumor necrosis factor production (GO:0032760)positive regulation of type II interferon production (GO:0032729)proteasomal protein catabolic process (GO:0010498)proteasomal protein catabolic process (GO:0010498)proteasomal ubiquitin-independent protein catabolic process (GO:0010499)proteasome complex (GO:0000502)proteasome complex (GO:0000502)proteasome core complex (GO:0005839)proteasome core complex (GO:0005839)proteasome core complex (GO:0005839)proteasome core complex, beta-subunit complex (GO:0019774)proteasome core complex, beta-subunit complex (GO:0019774)proteasome core complex, beta-subunit complex (GO:0019774)proteasome storage granule (GO:0034515)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein catabolic process (GO:0030163)regulation of G1/S transition of mitotic cell cycle (GO:2000045)regulation of proteasomal protein catabolic process (GO:0061136)regulation of proteasomal protein catabolic process (GO:0061136)response to oxidative stress (GO:0006979)response to oxidative stress (GO:0006979)response to type II interferon (GO:0034341)spermatogenesis (GO:0007283)structural constituent of proteasome (GO:0140756)synaptic vesicle (GO:0008021)thymic T cell selection (GO:0045061)

Expression (TPM)

TFs regulating PSMB3 0 TFs

Transcription factors with Perturb-seq knockdown data for PSMB3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMB3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PSMB3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMB3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:38,453,611–38,454,219	298.9 kb	Distal (>10kb) Multiome	168
chr17:38,509,961–38,510,926	242.2 kb	Distal (>10kb) Multiome	409
chr17:38,558,106–38,558,652	194.4 kb	Distal (>10kb) Multiome	631
chr17:38,559,205–38,559,900	193.1 kb	Distal (>10kb) Multiome	598
chr17:38,572,553–38,573,232	179.8 kb	Distal (>10kb) Multiome	231
chr17:38,604,448–38,605,250	147.8 kb	Distal (>10kb) Multiome	375
chr17:38,605,359–38,606,888	146.3 kb	Distal (>10kb) Multiome	781
chr17:38,609,172–38,610,061	143.1 kb	Distal (>10kb) Multiome	229
chr17:38,673,658–38,675,315	77.8 kb	Distal (>10kb) Multiome	847
chr17:38,701,857–38,703,072	50.4 kb	Distal (>10kb) Multiome	907
chr17:38,703,568–38,704,668	48.8 kb	Distal (>10kb) Multiome	955
chr17:38,704,725–38,707,220	47.4 kb	Distal (>10kb) Multiome	784
chr17:38,718,492–38,719,127	34.0 kb	Distal (>10kb) Multiome	268
chr17:38,719,228–38,720,635	32.5 kb	Distal (>10kb) Multiome	290
chr17:38,729,824–38,730,713	22.5 kb	Distal (>10kb) Multiome	794
chr17:38,747,498–38,750,334	2.9 kb	Proximal (<10kb) Multiome	914
chr17:38,751,747–38,753,201	980 bp	At TSS Multiome	986
chr17:38,789,155–38,789,604	36.7 kb	Distal (>10kb) Multiome	144
chr17:38,798,912–38,800,293	47.2 kb	Distal (>10kb) Multiome	966
chr17:38,824,673–38,825,720	72.6 kb	Distal (>10kb) Multiome	978
chr17:38,853,382–38,854,144	101.0 kb	Distal (>10kb) Multiome	1047
chr17:38,867,391–38,868,381	115.0 kb	Distal (>10kb) Multiome	640
chr17:38,869,253–38,871,194	117.1 kb	Distal (>10kb) Multiome	1074
chr17:38,900,769–38,901,637	148.6 kb	Distal (>10kb) Multiome	370
chr17:38,967,321–38,967,861	214.8 kb	Distal (>10kb) Multiome	219
chr17:39,011,896–39,012,455	259.4 kb	Distal (>10kb) Multiome	81

Genome Browser

Genomic view of the PSMB3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.