The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PSMB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:169,701,339–169,702,982 | 851.2 kb | Distal (>10kb) Multiome HiCAR | 1050 | |
| chr6:169,789,764–169,790,892 | 763.0 kb | Distal (>10kb) Multiome HiCAR | 772 | |
| chr6:170,289,086–170,292,550 | 262.4 kb | Distal (>10kb) Multiome | 490 | |
| chr6:170,295,396–170,297,381 | 257.3 kb | Distal (>10kb) Multiome | 655 | |
| chr6:170,306,110–170,307,169 | 246.7 kb | Distal (>10kb) Multiome | 935 | |
| chr6:170,552,943–170,554,837 | 1.0 kb | Proximal (<10kb) Multiome | 1097 | |
| chr6:170,584,110–170,585,439 | 31.4 kb | Distal (>10kb) Multiome | 965 |
Genomic view of the PSMB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.